“amount of RNA G-quadruplexes (rG4s) in hippocampal tissue increases as a function of age, and what’s more, it increases as a function of the severity of diagnosed Alzheimer’s at the time of death”

https://www.science.org/content/blog-post/neurodegeneration-might-come-down-rna

I have long thought Alzheimer’s is basically accelerated brain aging. If we live long enough we all get disabled.

“rG4 staining is also strongly influenced by the APOE4 status of the individuals”