“The slacker culture that prevailed from the late 1980s through the early 2000s was a glorious thing.”

Link. I did degrees in 78, 82, 86, 91, 94 and I’m doing a UMN class now. Undergrads now are way more keen, intense, and stressed.

I think students know we have too much worldwide talent for too little demand, that modern life is chaotic, technology is moving too fast, rural collapse is giving us Trump, and now AI is coming. Econ numbers miss this.

Lowe takes metformin primate results seriously.

Link. “Comparing RNA-seq and proteomics profiles of the two aged groups (treatment and control) with the two younger cohorts showed that metformin treatment rolled things back from 4 to 6 years”. 3 years of metformin for middle-aged cynomolgous monkeys.

I didn’t believe this result when I first read it. China has immense science fraud problems and the effect seems much too big. Published in Cell, but not, fwiw, in Nature or Science. I still think it’s too big an effect but if true it’s kind of Nobel gimme.

“certain brain networks, especially those involved in social and emotional processing, shrink during pregnancy”

Link. Similar to adolescent pruning of key neural networks. Suggests optimizing or locking-in some bonding behaviors that favor infant survival. (But may decrease maternal survival. )

“By the ninth week of gestation, 80 percent of 400 brain areas analyzed showed decreases in gray matter volume and cortical thickness that continued through pregnancy, with areas shrinking by 4 percent on average. Change was particularly pronounced in the default mode network, which is instrumental in perceiving other people’s feelings and perspectives.”

Rare article on how some Gazans see Hamas: “If you want to fight Israel, you should go do that. But why are you coming to hide among the civilians?”

Link. “Palestinians interviewed by The New York Times expressed frustration with Hamas, particularly over its practice of embedding in civilian areas”

“intelligence intercepts show that Hamas leaders have ordered their fighters to kill hostages if it appeared that Israeli troops were moving in and could potentially rescue them”

OpenAI’s “Strawberry”: “… complex planning or problem solving. It represents a huge leap in those areas.”

Link. I’ve read that while o1-preview is better at complex problems it tends to confabulate more. The good news is that at our current rate of improvement the AI impact will be more of a vast economic disruption precipitating a brewing “mass disability” socioeconomic crisis rather than the end of humanity. At least for the next 10 years.