Mudsills before Musk and Thiel

Link. “The “Mudsills” were dull drudges whose work produced the food and products that made society function. On them rested the superior class of people, who took the capital the mudsills produced and used it to move the economy, and even civilization itself, forward. The world could not survive without the inferior mudsills, but the superior class had the right—and even the duty—to rule over them.”

Heather Cox Richardson

Autonomous vehicles: A prediction

Link. “When autonomous vehicles are able to operate in Minnesota winters they will also be able to converse about quantum field theory, exotic mathematical geometries, politics in the Maldives, art history, and their latest contributions to classical music.”

Just putting down a marker.

GLP-1 inhibitors (or a derivative) likely to become standard therapy for OA knee pain

Link. Damn, this stuff is wild. 50% reduction in knee pain, nothing else but replacement comes close. Also, **FINALLY** word is getting out that OA is not “wear and tear”. Effect appears to be related to inflammation reduction and to maybe act at the joint (see also Alzheimer’s).

Personally I have impressive OA and remarkably little OA pain — and I have trouble keeping weight with my normal exercise addiction. I suspect GLP-1s wouldn’t help me much. But for most of the world …

“Scientific Reports has some serious problems with the papers it’s letting through … the publishers (Springer Nature) are not doing enough to address them”

Link. Science fraud is supported by the publishers of Nature.

“red flags for fraud … tortured phrases … irrelevant content, irrelevant citations, meaningless gibberish, a nonsensical figure, and material recycled from other publications.”

Hard to miss. Unless you want to not see.