Link. Damn, this stuff is wild. 50% reduction in knee pain, nothing else but replacement comes close. Also, **FINALLY** word is getting out that OA is not “wear and tear”. Effect appears to be related to inflammation reduction and to maybe act at the joint (see also Alzheimer’s).

Personally I have impressive OA and remarkably little OA pain — and I have trouble keeping weight with my normal exercise addiction. I suspect GLP-1s wouldn’t help me much. But for most of the world …