Link. “Comparing RNA-seq and proteomics profiles of the two aged groups (treatment and control) with the two younger cohorts showed that metformin treatment rolled things back from 4 to 6 years”. 3 years of metformin for middle-aged cynomolgous monkeys.

I didn’t believe this result when I first read it. China has immense science fraud problems and the effect seems much too big. Published in Cell, but not, fwiw, in Nature or Science. I still think it’s too big an effect but if true it’s kind of Nobel gimme.