Prevention of HIV with lenacapavir: trial “stopped at the interim analysis point for overwhelming efficacy”

Link. A celebration of med chemistry. “Molecular weight 968, ten fluorines, propargyl sulfone, fused cyclopropyl ring”.

” twice-yearly injections in thousands of female trial volunteers in high-risk areas (South Africa and Uganda) showed a one hundred per cent prevention rate of HIV infection.”

I didn’t realize quite what a jump this is. Great point is that this great success may make vaccine trials hard!