Inflammatory Bowel Disease: “tweaking ETS2 to be more active could make macrophages in the lab resemble the ones seen in IBD patients.” 🆓

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Link. “when they looked at the genetic make-up of IBD patients, they found that 95% of patients in their sample carried at least one copy of a specific enhancer variant that seems to boost ETS2 activity…

… MEK inhibitors, should be able to quiet down the inflammation triggered by ETS2”

If it holds up … it’s big.