“chances of finding a de novo mutation go up if a patient has severe autism and other, co-occurring conditions, like epilepsy, movement disorders or an intellectual disability. “

https://www.seattletimes.com/nation-world/a-furious-debate-over-autisms-causes-leaves-parents-grasping-for-answers/

De novo mutations are mistakes during routine DNA manipulation, not inherited. Autism is a crap syndromic term for a wide range of conditions many of which are associated with a variety of inherited and de novo mutations in a wide variety of proteins. There really doesn’t seem to be a single cause to focus on.

Judge Mark Wolf, American patriot: why he resigned to fight for democracy

https://heathercoxrichardson.substack.com/p/november-9-2025

“Trump’s use of the Department of Justice to hurt his political opponents, his firing of inspectors general, the administration’s pay-to-play policies in which wealthy donors get government favors, the corruption of cryptocurrency, unconstitutional executive orders, and the threats against judges as Trump attacks the rule of law.”

“after 80 years of on-and-off support for the Palestinian cause the [arab] regimes have finally written them off”

https://gwynnedyer.com/2025/arab-nadir-clueless-hegemons/

“highest policy priority of Israel’s immediate neighbours, Egypt, Jordan, Syria and Lebanon, is not to prevent the ethnic cleansing of the Palestinians. It is rather to ensure that the new wave of Palestinian ‘refugees’ does not end up on their territories”

“When you look at what’s driving electricity bills, it’s really poles and wires”

https://www.nytimes.com/2025/10/30/climate/electricity-prices.html

Mostly not data centers or generation costs.

“utilities have nearly tripled the amount they spend annually on the network of poles, wires, substations and transformers … Large portions of the electric grid are nearing the end of their 50-year life spans …deal with storms, fires and heat waves …”

LLMs enabling Data Freedom between apps

https://www.macstories.net/notes/llms-for-data-portability/

“I opened Claude for Mac, installed one of its built-in Notes extensions, and asked it to replicate content from a specific folder of the Notes app in a Notion database while keeping as much of the original formatting intact as possible.”

This is very encouraging. One day I hope an LLM will free my blogs from Blogger (existing migration options suck).

Brooks: “humanoid robots will be “plug compatible” with humans and be able to step in and do the manual things that humans do … believing that this will happen any time within decades is pure fantasy thinking”

https://rodneybrooks.com/why-todays-humanoids-wont-learn-dexterity/

His voice carries weight.

“Schunk, a German company, sells over 1,000 varieties of parallel jaw grippers, both electric and pneumatic (using compressed air), for robot arms.”

Trump’s insurrection strategy.

https://heathercoxrichardson.substack.com/p/october-30-2025

The Epstein files must hold a dead body somewhere. Trump goes to insurrection when squeezed.

“The establishment of a domestic quick reaction force to quell civil disturbances at a time when there are no civil disturbances that can’t be handled easily by existing law enforcement suggests the administration is expecting those conditions to change”